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lumefantrine will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.rufinamide will decrease the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.If unable to stay clear of coadministration of belzutifan with sensitive CYP3A